2010 IR Workshop

Paul Dumas

[Click here for the talk abstract]

Biography

Dr. Paul Dumas is Research Director at the CNRS, and beamline manager of the Infrared Station at the French National Synchrotron facility, SOLEIL. He promoted this analytical technique in France, at LURE, where he was responsible for the design and construction of an infrared microscope beamline at LURE, the French National synchrotron Center, until its closing in December 2003.

His research program, apart for surface science, includes studies of individual cells in Biology, geological inclusions, astrophysics, soft matter and archeology. He is also member of several Scientific Advisory Committees and Program Review Committees of  Synchrotron facilities around the world.

Abstract

Does Synchrotron Infrared Micro-spectroscopy Significantly Contribute  to New Knowledge in Biology and Biomedicine ?

Several synchrotron infrared beamlines witness an important motivation expressed by the biological and biomedical communities, often exceeding more than 50% of the total beam time requests of the other scientific disciplines.

In France, the infrared beamline, named SMIS (Spectroscopy and Microscopy using Infrared Synchrotron) at SOLEIL synchrotron facility (www.synchrotron-soleil.fr) is operating two branches simultaneously, one of them being fully dedicated to biological and biomedical applications. The highest demand is rather in good quality spectra at the highest spatial resolution possible. Single cell analysis is an important research area, in the study of stem cell differentiation and reprogrammation, of leukemia cells and drugs interaction, on cancer cells and treatment. Besides study of individual cells, human tissues have been investigated, with recent interesting findings on Hungtinton disease, and liver steatosis.

Two important researches have found their way to biomedical application. Identification of the nature of kidney stones, of few microns size, is routinely carried out to initiate treatment that allows kidney function recovery (collaboration with Necker Hospital in Paris) . Liver studies has led to identify unusual lipids concentration on biopsies, that can be directly related to steatosis content, with a more secure number that the one evaluated by pathologists upon visual inspection. The technique, after being completely validated with the previous synchrotron data, will exploited the internal source and be transferred, to hospital (Institute Hepato-Biliare, Brousse Hospital, Villejuif, France) within 6 months.

Several of the current researches at SMIS beamline will be presented, in order to demonstrate that, as in many other synchrotron facilities worldwide, biological and biomedical studies are benefiting a lot for the source brightness of the synchrotron radiation in the infrared region.